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White Papers by Tosoh

Process Analytics and Intermediate Purification of Bispecific Antibodies with a Non-Affinity Platform

| Contributed by Tosoh

Modern chromatography resins were evaluated for the purification of a bispecific antibody.

Increase mAb purity with salt-tolerant cation exchanger

| Contributed by Tosoh

The strong cation exchange resin TOYOPEARL Sulfate-650F offers high salt-tolerance, wide working pH range, and high dynamic binding capacity.

Antibody-Drug Conjugate Mimic Purification with TOYOPEARL® PPG-600M HIC RESIN for DAR-Separation

| Contributed by Tosoh

Antibody-drug conjugates (ADCs) are promising anti- cancer biopharmaceuticals with one of the highest annual growth rates. Four ADCs received market approval to this point.

Effective Removal of Endotoxins with AEX RESIN TOYOPEARL® NH2-750F

| Contributed by Tosoh

TOYOPEARL NH2-750F is a salt-tolerant anion exchange resin well known for being capable of aggregate removal in both flow-through and bind / elute modes. Here, we demonstrate that the salt-tolerant TOYOPEARL NH2-750F is a very effective resin for the removal of endotoxin in a flow-through chromatography mode as well.

SEC/MS Analysis of a Bispecific Antibody

| Contributed by Tosoh

More potent formats of monoclonal antibodies (mAbs), such as bispecific antibodies (bsAbs), are on the rise in the area of biotherapeutics.

MAb Aggregate Removal through IEC in Bind/Elute and Flow-Through Mode

| Contributed by Tosoh

Purification schemes for monoclonal antibodies typically consist of three chromatographic steps accompanied by filtration steps.


| Contributed by Tosoh

An application example for the general method set-up and optimization

Continuous chromatography for the purification of biomolecules

| Contributed by Tosoh

There is a growing interest in the development of continuous biomanufacturing systems to increase productivity and reduce costs.

Increase Monoclonal Antibody Purity with TOYOPEARL® Sulfate-650F C-IEX Resin for Capture and Removal of mAb Aggregates

| Contributed by Tosoh

TOYOPEARL Sulfate-650F cation exchange resin can be used for the removal of aggregates, host cell proteins and leached protein A in a single post Protein A mAb polishing step.

How to improve performance of the Protein A capturing step

| Contributed by Tosoh

Protein A has become a well-established platform for capturing of monoclonal antibodies and Fc-fusion proteins.

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