Newsletter - 0717-08
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Top Articles
When the Stars Align
The next wave of highly potent small molecule drugs poses a serious challenge to current batch manufacturing infrastructure, but achieving cGMP and strict regulatory compliance with continuous alternatives can be challenging. Yet Eli Lilly has found a way with prexasertib.
Science Versus Trump
President Donald Trump’s budget request for 2018 caused a huge stir in the scientific community because of its potential impact on research. Catherine Bollard, President of the ISCT, argues that the proposed cuts would be detrimental to global health – not just the health of Americans.
The Value of Giving Back
Fred Bereskin says that pharmaceutical firms are some of the most generous, in terms of their philanthropy; however, not all companies understand how philanthropy can ultimately benefit innovation and help develop partnerships with outside organizations.
Upcoming Webinar
Practical Considerations for Overcoming Bioavailability Challenges
Lipid-based drug delivery systems (LBDDS) have helped bring more than 50 poorly soluble NCEs to market, but functional excipients and formulation expertise are crucial. In this webinar, two experts discuss the importance of excipient selection and the technical benefits of combining LBDDS and softgel technologies
Application Notes
Addressing the needs of drug discovery with the MicroCal PEAQ-ITC instruments
This white paper highlights the advantages of the new ITC instruments—MicroCal PEAQ-ITC and MicroCal PEAQ-ITC Automated systems and MicroCal PEAQ-ITC Analysis Software. The software allows analysis of binding interactions complicated by the presence of inactive protein material, incorrect protein concentration, and/or inaccurate concentration or heterogeneity of compound solutions.
The new MicroCal PEAQ-DSC Automated system
Differential scanning calorimetry (DSC) is an established biophysical tool for protein stability characterization during biopharmaceutical drug development. This whitepaper discusses the new and improved features of the MicroCal VP-Capillary DSC system, including PEAQ-Compliance, PEAQ-Smart, PEAQ-Finder, PEAQ-Performance and PEAQ-Compare, which make DSC even easier to use, and produce reliable, reproducible DSC data.
Multi Column Chromatography: Number of Columns Required for Optimizing Capacity and Productivity
In this application note, the Protein A mAb capture process is modeled with a focus on the benefits of multi-column chromatography vs. single column operation. Here we explore the relationship between operating binding capacity, residence-time, productivity, and the total number of columns required for optimal operation.
Product Profiles
Highly Potent API Development & Manufacturing Services
Cambrex offers clients a truly end-to-end partnership for the research, development and manufacture of small molecule highly potent APIs (HPAPIs) across its global manufacturing network, to support a drug at every stage of its lifecycle.
Capsules, the very essence of Qualicaps
Building on nearly 120 years of experience, Qualicaps® created the first gelatin capsule for inhalation through DPI devices, and subsequently the first hypromellose capsule, Quali-V®-I, for the same purpose, but specially formulated to achieve exceptional puncturing performance, optimal aerosolization properties, minimal microbial levels, and reduced static charge.
Event Profile
Further Growth for Sixth Edition of Pharma Integrates
A packed programme will challenge established paradigms and discuss new models of pharmaceutical production. With 90+ confirmed panellists and 350 delegates, three headline on-stage interviews will complement this year’s debate-led sessions. Book your place, get involved and influence future pharma thinking.
Upcoming Events
Be it a large congress at a huge venue or an expert meeting that fits around a table, these events are a fantastic way to network and educate yourself on the latest developments in the industry – so why not take a look at our list of upcoming events?