Newsletter - 0818-03
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Issue #0818
 
 
Top Articles
 
 
Faster for Pharma
 
We sit down with Melissa Hanna-Brown, Analytical Technology & Innovation Lead for Pfizer Global R&D, to discuss accelerating new medicines, and how analytical science can serve pharma.
 
 
 
 
Packaging for the Elderly
 
Over 597 million people in the world are 65 or over – and the elderly population is only growing. So why are we still making packaging they find difficult to open? asks Stephen Wilkins.
 
 
 
 
Pharma Fiction
 
Could this be your next TV series to binge-watch? A new Netflix show, Maniac, will tell the story of two patients caught in a clinical trial gone seriously awry. Pharma’s onscreen reputation strikes again…
 
 
 
 
 
 
 
Webinars
 
 
Assessing Critical Quality Attributes and Structural Conformation of Biotherapeutics by HDX-MS
 
Hydrogen deuterium exchange (HDX) mass spectrometry (MS) is a powerful tool for studying the dynamics of higher order structure of protein-based therapeutics. Learn from experts at Genentech and Thermo Fisher Scientific how HDX-MS can be employed to monitor critical quality attributes of protein therapeutics.
 
 
 
Accurate peptide retention data collection for retention modeling studies using the Q Exactive HF-X Orbitrap mass spectrometer
 
This webinar will provide a step-by-step guide for construction of a peptide retention library using 2D LC-MS/MS (Q Exactive HF-X Orbitrap) analysis of whole cell tryptic digests. The major parameters of separation system affecting separation selectivity as well as chromatographic quality control will also be covered.
 
 
 
 
White Papers
 
 
TOYOPEARL PPG-600M: the HIC resin for the purification of ADCs
 
Antibody-drug conjugates (ADCs) are promising anticancer biopharmaceuticals with one of the highest annual growth rates. For their purification, the best Hydrophobic Interaction Chromatography (HIC) resin is TOYOPEARL PPG-600M. It offers the benefits of a high recovery together with a high binding capacity, and a wide working pH range.
 
 
 
Using laser diffraction particle size analysis to support early stage product development
 
Measuring particle size at an early stage in development is therefore of significant benefit to researchers who need to engineer specific product attributes.
 
 
 
Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology
 
In this application note, a commercially available sample of PCL was extruded alone and in the presence of CO2­. Multi-detector GPC measurements were made of the virgin sample before and after extrusion, while rotational rheometry was used to study the polymer’s melt viscosity.
 
 
 
 
Product Profile
 
 
Early Drug Formulation and Development
 
Catalent has a broad range of experience and expertise in early phase development, and has tools including its proprietary OptiForm® Solution Suite platform to optimize development programs; accelerating molecules from late-stage discovery to Phase 1 clinical trials.
 
 
 
 
Special Promotions
 
 
Essential Technology in the Pharma Toolbox
 
Where would drug development be without liquid chromatography-mass spectrometry – the hyphenated technique more commonly known as LC-MS? Here, we speak with expert LC-MS user Brunhilde Guessregen, who describes its importance in impurity profiling and structure elucidation at Merck.
 
 
 
Development of a Scalable Viral Vector Upstream Process for Gene Therapy
 
The next generation iCELLis® Nano bioreactor makes process development and small-scale production of virus easy and straightforward. When larger scales are required, processes developed in the iCELLis Nano bioreactor can be easily transferred to the iCELLis 500 bioreactor system, the perfect solution to GMP production.
 
 
 
Join us at the inaugural BioPharma Trends conference: Towards Industry 4.0
 
Cloud computing, big data, smart technology, integrated systems... Industry 4.0 is already here. But which elements can benefit biopharmaceutical manufacturing now and in the future? Join us at Biopharma Trends 2018: Towards Industry 4.0 to find answers.
 
 
 
 
Events
 
 
Upcoming Events
 
Be it a large congress at a huge venue or an expert meeting that fits around a table, these events are a fantastic way to network and educate yourself on the latest developments in the industry – so why not take a look at our list of upcoming events?