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Manufacture Small Molecules

Moving from Batch to Continuous

| James Strachan

The first switch from batch to continuous manufacturing has been made – and approved by the FDA. Will pharma’s future be continuous?

Discovery & Development Analytical Science

Affliction Prediction

| James Strachan

Could drug development be guided by a new algorithm that predicts the side effects of potential medicines?

Discovery & Development Formulation

As Clear as Crystallization

| James Strachan

Functionalized glass is shown to trigger nucleation of specific crystal forms

Business & Regulation Business Practice

Parting Shot

| James Strachan

Sir Andrew Witty seeks to cement his legacy as GSK addresses patents and medicines access in the developing world

Manufacture Drug Delivery

Harnessing Adeno-Associated Viruses

| James Strachan

AAV vectors are a promising tool for gene therapy and regenerative medicine, but only if they can be manufactured efficiently

Discovery & Development Technology and Equipment

Bio-Responsive Insulin Delivery

| James Strachan

A “smart” synthetic patch uses live pancreatic cells to painlessly deliver insulin through microneedles – on demand

Business & Regulation Business Practice

Mega-Merger Not To Be

| James Strachan

A newly introduced tax law in the US puts an end to the would-be mega-merger between Pfizer and Allergan

Business & Regulation Business Practice

A Battle of the Sexes

The Power List is back, but is it a fair representation of the male to female ratio in our industry?

Discovery & Development Business Practice

Morphologically-Directed Raman Spectroscopy used for the characterization of protein aggregates in suspension

This application note explores the use of the Morphologi G3-ID for Morphologically-Directed Raman spectroscopy (MDRS) to identify and analyze contaminants including protein aggregates present in a stressed sample of lysozyme, and to compare particles held in suspension within a thin path wet cell with those collected on a filter membrane.

Discovery & Development Formulation

Therapeutic protein products used for the differentiation and characterization of subvisible particulates

This application note provides an example of how Archimedes can be used to detect and quantify the formation of protein sub-visible particles and the introduction of silicone oil droplets, in response to shear stress.

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