Bringing mRNA & LNP to life takes more than experience; it takes passion.
Simplify the Journey of Advancing Your Therapies to Patients
Regardless of whether you're in the early stages of ideation, scaling up your production, or seeking technical and regulatory expertise for a successful drug launch, having a reliable CDMO partner can make a significant difference.
With Merck’s extensive expertise in mRNA, lipids, and LNPs, we're here to help you through each phase of your journey from pre-clinical to commercialization. Our goal is to provide the resources and expertise you need to progress your program with confidence. Select from end-to-end or standalone offerings, tailored to your path and pace:
• mRNA drug substance
• lipid manufacturing
• LNP formulation & manufacturing
• Fill & Finish
Benefits of PCR-based mRNA Manufacturing Processes White Paper
Learn about the advantages of PCR-based mRNA manufacturing as a robust alternative to linearized plasmid-based synthesis. This solution combines the high-quality advantages of synthetic templates with high accuracy and scalability. Thereby, we can assign the high accuracy of PCR to mRNA production. This inimitable combination allows mRNA manufacturing with a unique set of advantages.
DownloadHigh-performing ionizable lipids: Practical applications for controlled & safe nucleic acid delivery Webinar
Explore the critical role of ionizable lipids in LNP formulations and gain insights into our capabilities for customized LNP formulation development for novel therapeutic modalities. The webinar covers essential topics, including screening, optimization, analytical characterization, in vivo testing, and scale-up strategies for LNPs. Discover the significance of LNPs in advancing therapeutic modalities and improving patient lives.
View hereConsiderations for Advancing a Lipid Nanoparticle Formulation to Clinical and Commercial Manufacturing White Paper
Selection of the right lipids with the appropriate quality impacts both the final LNP drug product as well as the LNP process. This white paper provides an overview of critical quality considerations for lipids and describes the process requirements for successful commercial scale manufacturing.
DownloadFill & Finish Services – Supporting Complex Manufacturing for Liquid and Lyophilized Drug Products Tech Note
Learn about a powerful solution for versatile, precise, and efficient aseptic filling of drug products. With advanced recovery filling and lyophilization capabilities, combined with rapid turnaround times,
our isolator Fill & Finish line is uniquely designed to support both small early-phase manufacturing and commercial GMP batches ensuring critical programs move smoothly from the lab to the patient.
DownloadRegulatory Expertise and CMC Document Preparation to Support mRNA-based Therapeutic Development
This article provides an overview of the regulatory expectations applicable to mRNA drug substance and product, the need for phase-appropriate quality, and insights into the development of CMC documentation that help ensure compliance.
DownloadCDMO Services: Customized mRNA-LNP Solutions Infographic
Feel the difference with a passionate CDMO partner committed to your mRNA & LNP success. Discover our GMP-ready, fully connected services — from DNA to lipid manufacturing, LNP formulation and manufacturing, and Fill & Finish.
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