Full structural characterization is critical in biopharmaceutical development where the subtle but critical local conformational changes of a therapeutic protein can impact safety and efficacy.
Hydrogen deuterium exchange (HDX) mass spectrometry (MS) is a powerful tool for studying the dynamics of higher order structure of protein-based therapeutics. The rate of hydrogen-to-deuterium exchange within the amide hydrogen on the backbone of biotherapeutics provides solvent accessibility information and thus protein structure and conformation can be inferred.
Learn from experts at Genentech and Thermo Fisher Scientific how HDX-MS can be employed to monitor critical quality attributes of protein therapeutics.
See how Orbitrap-based HDX MS using the Thermo Scientific Orbitrap Fusion Lumos Tribrid MS offers a robust method for the analysis of protein conformation and conformation dynamics. Join the webinar to hear how advanced ionisation techniques give additional structural insights into protein conformation.
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