A new strategy using real-time background subtraction data acquisition on a tribrid Quadrupole-IonTrap-Orbitrap HRMS system is developed for in-vitro and in-vivo characterization of drug metabolites. It enables the possibility of collecting comprehensive MS full-scan and MSn scan spectra of the metabolites of interest without prior knowledge and prediction of metabolic pathways. Advanced post-acquisition analysis tools are readily utilized for in-depth data mining and structural elucidation.
Learning Objectives of Webinar
Learn the cutting-edge technology of the tribrid mass spectrometry.
Understand the new concept of advanced data-acquisition strategy.
Learn the application on characterization of drug metabolites.
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