July 21, 2020
1pm EDT
Upstream process intensification efforts are becoming mainstream in every biopharma R&D lab and clinical program. The ability to scale down these processes has been limited due to the lack of appropriate equipment to perform perfusion cultures at scale less than 2-3L, which are costly to operate. Erbi Biosystems’ fully closed, single-use, perfusion bioreactor operates at a 2 mL working volume and can replicate bench scale perfusion processes to industrially relevant cell densities. To achieve this level of performance in such a small form factor Erbi Biosystems has incorporated bubble free mixing, on-line sensors, automated bleeds, automated pH control, and integrated software-controlled operation providing deeper process insights.
Learning Objectives:
Introduce a small scale, high performance perfusion bioreactor option
Demonstrate how a 2 mL scale working volume bioreactor provides stirred tank performance
Demonstrate how customers can grow/maintain high cell densities up to 250M/mL
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