5 Key Takeaways

• 1

  NewBiologix developed the NBX1P01 clonal HEK293 cell line for enhanced recombinant adeno-associated virus (rAAV) production.

• 2

  NBX1P01 achieved a two-fold higher full-to-empty rAAV capsid ratio compared to a leading commercial HEK293 cell line.

• 3

  The cell line demonstrated genomic stability over 55 population doublings with lower genetic heterogeneity than parental HEK293.

• 4

  Long-read sequencing confirmed over 70% intact rAAV genomes with minimal encapsidated contaminating DNA.

• 5

  NBX1P01 supports scalable production from 10 mL to 1.5 L and is versatile for multiple rAAV serotypes and transgene sizes.