5 Topic Commentaries

How Genomics Is Personalizing Drug Discovery

• 

  Richard M. Weinshilboum, M.D.

  Clinical pharmacology; pharmacogenomics

  •

  Mayo Clinic

  This “therapeutic revolution,” has brought us to pharmacogenomics, where we’re scanning the genome to try to cure, even prevent diseases. The future is not around the corner. It’s now. The goal is to deliver the right drug at the right time in the right dose to the right person, and eliminate treatments that don’t work.

  Source
• 

  Stuart L. Schreiber, Ph.D.

  Chemical biology; drug discovery

  •

  Broad Institute of MIT and Harvard

  When you rely on biology — not models but real humans — to reveal the root cause of the disease, the good news is you can discover insights for even the most daunting ones, like schizophrenia.

  Source
• 

  Lei Zheng, M.D., Ph.D.

  Medical oncology; pancreatic cancer; immunotherapy

  •

  Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center

  But what if we had an assay to predict the patients’ response to one specific component or a combination of components among the five drugs we would be able to further lower the toxicity and treat the cancer more precisely. This is what precision medicine is all about. Getting patients just the right treatment—not too much and not too little.

  Source
• 

  Louis M. Staudt, M.D., Ph.D.

  Cancer genomics; hematologic oncology

  •

  National Cancer Institute, National Institutes of Health

  We’re moving from histological diagnosis to genomic diagnosis as fast as we can.

  Source
• 

  Scott Gottlieb, M.D.

  Regulatory science; medicine

  •

  U.S. Food and Drug Administration

  Today is an important milestone in a long journey we've been on to transform clinical medicine by using modern advances in genomics.

  Source