5 Key Takeaways

• 1

  The report described 14 pregnancies in 13 patients who had received CAR T-cell therapy for autoimmune disease.

• 2

  No autoimmune disease flares occurred during pregnancy, and all but one patient remained drug-free or used only prophylactic hydroxychloroquine.

• 3

  Eight healthy babies had been born, five pregnancies were ongoing, and one pregnancy was electively terminated for reasons unrelated to autoimmune disease.

• 4

  Newborns had no detectable CAR T cells, and reported CD19-positive B-cell counts, immunoglobulin G levels, and early development were normal.

• 5

  The researchers called for pregnancy registries and further studies of fertility after lymphodepletion and CAR T-cell treatment.