5 Key Takeaways

• 1

  Researchers identified SRSF1 through a machine learning screen designed to find genes that make aged cells more youthful while preserving cell identity.

• 2

  In human fibroblasts, SRSF1 overexpression reduced senescence, inflammatory signaling, and proteostatic stress while restoring DNA repair programs.

• 3

  In aged female mice, inducible SRSF1 delivery increased median lifespan from 778 to 886 days and reduced the rate of frailty accumulation by approximately 44%.

• 4

  SRSF1 treatment delayed the onset of sustained frailty by 123 days, and its effects depended on controlling expression timing and level.

• 5

  The findings are preclinical, come from a small mouse cohort, and the mechanisms linking SRSF1-mediated RNA processing to the observed effects remain under investigation.