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Business & Regulation Formulation, Business Practice, Drug Delivery, Standards & Regulation, Trends & Forecasts

A Cat and Mouse Game: The Evolving Landscape of Abuse-Deterrent Formulations

What are some of the main formulation strategies you use to deter abuse?

Liquid and semi-solid filled capsule products can be formulated to provide a number of physical barrier mechanisms, singly or in combination, to deter manipulation and abuse:

  • It provides a liquid or semi-solid (waxy) base, which makes snorting impossible, and cannot be modified by grinding.
  • The same base provides the first step in modifying the viscosity of the formulation to prevent injection by syringe.
  • Adding excipients or gelling agents to the formulation can further enhance the prevention of syringing.
  • The added gelling agent and base excipients also act together to inhibit liquid extraction of the API, and maintain the selected release rate even when manipulated or chewed.
  • Whilst the technology is intended to provide barrier mechanisms to abuse, it is perfectly compatible with the addition of agonists or aversion systems, which are used to either reduce the clinical activity of the API or create an unpleasant effect when the product is abused.

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About the Author

Charlotte Barker

As an Editor at Texere, I’m working closely with our audience to create vibrant, engaging content that reflects the hard work and passion that goes into bringing new medicines to market. I got my start in biomedical publishing as a commissioning editor for healthcare journals and have spent my career covering everything from early-stage research to clinical medicine, so I know my way around. And I can’t think of a more interesting, challenging or important area to be working in.

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