A Cat and Mouse Game: The Evolving Landscape of Abuse-Deterrent Formulations
Abusers are finding ways to circumvent current abuse-deterrent measures, leaving companies in need of new strategies. Alyn McNaughton, Director of Analytical and Product Development at Encap Drug Delivery, a division of Capsugel Dosage Form Solutions, and Shonagh Walker, Formulation Scientist at Encap Drug Delivery, talk us through some of the challenges.
Charlotte Barker |
What are some of the main formulation strategies you use to deter abuse?
Liquid and semi-solid filled capsule products can be formulated to provide a number of physical barrier mechanisms, singly or in combination, to deter manipulation and abuse:
- It provides a liquid or semi-solid (waxy) base, which makes snorting impossible, and cannot be modified by grinding.
- The same base provides the first step in modifying the viscosity of the formulation to prevent injection by syringe.
- Adding excipients or gelling agents to the formulation can further enhance the prevention of syringing.
- The added gelling agent and base excipients also act together to inhibit liquid extraction of the API, and maintain the selected release rate even when manipulated or chewed.
- Whilst the technology is intended to provide barrier mechanisms to abuse, it is perfectly compatible with the addition of agonists or aversion systems, which are used to either reduce the clinical activity of the API or create an unpleasant effect when the product is abused.
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