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Real-time particle sizing for granulation control

Benefit of laser diffraction and spatial filter technique for dry and wet granulation

Across the pharmaceutical, food and chemical industries, granulation processes are used to convert light, fine powders into larger, more dense granules, to make fast-dissolving drinks, optimized blends for compression tableting and granules for waste water absorption applications, for example. Also in the manufacture of catalysts. Whether granulation is dry or wet the goal is to produce granules that fulfill the requirements of subsequent processing steps or end use. Particle size is often a defining characteristic.

This paper considers various granulation processes and the use of real-time particle size measurement in their optimization, focusing on two different sizing methods: laser diffraction and the spatial filter technique (SFT). Case studies illustrate the potential benefits associated with continuous particle size measurement.

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