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Cell and Gene

Welcome to our coverage of cell and gene therapy! Did you know The Medicine Maker team also produces a weekly "Cell and Gene" newsletter, featuring research and business news, expert insight, and regulatory updates? Subscribe here ...


Manufacture Advanced Medicine

The Future Awakens

| Sponsored by Eppendorf, Millipore Sigma, Thermo Fisher Scientific & Miltenyi Biotec

Experts in the cell and gene therapy space are excited about things to come. After all, these are the pioneers of a burgeoning field of medicine.

Manufacture Advanced Medicine

Time Machine

| Sponsored by Eppendorf, Marken, Sartorius

Step into a future where science fiction meets reality – the world of cell and gene therapies.

Discovery & Development Drug Discovery

The Power of Genetics

| 2 min read

Regeneron’s Gary Herman discusses the future of genetic medicines and the role of new delivery systems.

Discovery & Development Drug Discovery

Herd Mentality, Cell Therapy, and Pharma’s Future

From overcoming herd mentality in research to expanding cell therapy applications in cancer treatment, we explore the future of pharma.

Discovery & Development Advanced Medicine

Giving the GIFT of Genomic Mapping

| Rob Coker | 4 min read

Manufacture Advanced Medicine

Navigating the Challenges – and Opportunities -of Lentiviral Vectors

| Sponsored by Sartorius | 7 min read

Lentiviruses are growing in the advanced therapy landscape. Experts at Sartorius discuss the unique challenges that come with their production

Manufacture Advanced Medicine

Next Generation CRISPR

| Venkata Indurthi | 3 min read

The pipeline of early-stage CRISPR therapeutics is huge, but advancing these innovations will require a multifaceted strategy.

Manufacture Advanced Medicine

The Status Quo of Oligonucleotides Is Not the Future

| Sponsored by Asahi Kasei Bioprocess | 7 min read

The science of oligonucleotides is advancing, but advanced manufacturing techniques are needed to optimize their impact

Manufacture Advanced Medicine

At the Cutting Edge

| Alexander Seyf

How digital technology has, and will continue to, augment scientific data collection and discovery

Manufacture Advanced Medicine

The Synergy of Science and Business

| Stella Vnook | 3 min read

Developing science is good; developing successful commercialization strategies is great.

Manufacture Advanced Medicine

Allogeneic: The Next Stage For the Cell Therapy Story

| Bill Vincent | 4 min read

Cell therapy has come a long way since the 1930s. Next, we need to find a way to bring the costs down by using allogeneic approaches.

Manufacture Advanced Medicine

Facing Up to the Challenges in Cell Therapy

Jason Bock highlights the need for innovative manufacturing solutions and supply chain improvements in cell therapy.

Manufacture Advanced Medicine

Get into My Car(-T)

| Ignacio Nunez, Josh Ludwig | 6 min read

Why cell and gene therapy manufacturing has a lot to learn from the automotive sector.

Manufacture Advanced Medicine

Integrated Expertise

| 7 min read

Experts from Lonza share how biologics and CGT can recognize the gaps and similarities that can be utilized to optimize cell culture media challenges.

Discovery & Development Advanced Medicine

Victor Ambros and Gary Ruvkun share 2024 Nobel Prize for Physiology or Medicine

| Rob Coker

The Nobel Prize for Medicine has again been awarded jointly, this time for miRNA discovery and its role in gene regulation

Discovery & Development Drug Discovery

Cell Wars: A New Hope

| Rob Coker

Researchers use AI to reprogram glioblastoma cancer cells

Manufacture Advanced Medicine

Future Pharma

| Rob Coker | 4 min read

Ever wondered what the distant future of pharma and healthcare looks like? A group of industry experts offer their sage predictions.

Manufacture Advanced Medicine

eBook: Catching Up With Cell and Gene Therapy

Our special series eBook covers some of the hottest topics in cell and gene therapy including closed processing and more.

Manufacture Advanced Medicine

New Platform, New Potential

| 16 min read

We get the background on a new manufacturing platform for cell and gene therapy from Ori Biotech, tested by MD Anderson and Resilience’s CTMC.

Manufacture Advanced Medicine

Advanced Transformation

| 7 min read

Software development and CDMO experts share their key tips for choosing the right digital technologies and partnerships

Manufacture Advanced Medicine

The Digital Dream

| Alexander Seyf | 4 min read

Digitalization can transform the operation and performance of the cell and gene therapy manufacturing space, to the benefit of all.

Manufacture Advanced Medicine

Vector Connector

| 7 min read

A panel of experts discuss the trends and innovations in the viral vector-based therapy sector at the ASGCT.

Manufacture Advanced Medicine

Everybody Inspires

| 7 min read

Sitting Down With… Claudia Zylberberg, Akron Bio Founder and ICST Presidential Nominee

Discovery & Development Advanced Medicine

Pleading the CAR-T Case

| Jamie Irvine | 2 min read

Large study shows secondary tumors after CAR-T cancer therapies are rare

Manufacture Advanced Medicine

The Elite Athlete Concept for Cell Therapy

| Yelena Bronevetsky, James Lim | 4 min read

How metabolic conditioning could improve cell therapy potency and persistence.

Manufacture Advanced Medicine

Preservation and Perseverance

| 5 min read

Sitting Down With… Stella Vnook, CEO, Likarda

Manufacture Advanced Medicine

Enter Exon Editing

| Michael Ehlers | 4 min read

If we can edit RNA at the kilobase scale, we can treat more diseases at the genetic level

Manufacture Advanced Medicine

Advanced Therapies, Archaic Hardware: the Perils of Paper

| Matt Todd | 4 min read

Here’s how paper is weighing down the future of advanced therapies.

Manufacture Advanced Medicine

The Future of Cell and Gene Therapy Purification

| Sponsored by Astrea Bioseparations | 4 min read

How Astrea Bioseparations is expanding its expertise into the advanced medicines space.

Manufacture Advanced Medicine

Introducing a Regulatory Playbook for Gene Therapy

| Stephanie Vine

In this video interview, Courtney Silverthorn explains the inspiration behind a free regulatory playbook for gene therapy manufacturers.

Manufacture Advanced Medicine

Interviewing Luigi Naldini: Be a Little Different

| Stephanie Vine | 8 min read

How the drive to try something new led to the development of lentiviral vectors for gene therapy.

Manufacture Advanced Medicine

Cell and Gene Therapies: Live at Phacilitate with Stella Vnook, CEO, Likarda

Discussing the trends in cell and gene therapeutics, with Stella Vnook, CEO, Likarda

Manufacture Advanced Medicine

Cell and Gene Therapies: Live at Phacilitate with Joel Eichmann, CEO, Green Elephant

Discussing the trends in cell and gene therapeutics, with Joel Eichmann, CEO, Green Elephant, live at Phacilitate

Manufacture Advanced Medicine

Cell and Gene Therapies: Live at Phacilitate with George Eastwood, Board Member, Emily Whitehead Foundation

Discussing the trends in cell and gene therapeutics, with George Eastwood, Board Member, Emily Whitehead Foundation

Manufacture Advanced Medicine

Cell and Gene Therapies: Live at Phacilitate with Delara Motlagh, Head of Global Cell Therapy, Catalent

Discussing the trends in cell and gene therapeutics, with Delara Motlagh, Head of Global Cell Therapy, Catalent

Manufacture Advanced Medicine

Cell and Gene 4.0

| 14 min read

May the fourth industrial revolution be with you…

Manufacture Advanced Medicine

Towards Rapid Microbial Testing Methods

| Michaela Doláková, Nikola Pinďáková, Veronika Horková, Václava Bauerová, Klára Sochorová, Daniela Rožková | 4 min read

We need more rapid sterility testing methods for frozen CAR-T drug products; here’s one potential approach

Manufacture Advanced Medicine

Getting Off to a Good Start

| Priya Baraniak | 8 min read

Why finding high-quality donor cells is so important in cell therapy development

Manufacture Advanced Medicine

Open or Closed?

| Krishnendu Khan | 5 min read

How to find the right balance in cell therapy manufacturing.

Manufacture Advanced Medicine

Interviewing Paul Donohoue: A Guiding RNA-DNA Light for CRISPR

| Stephanie Vine | 12 min read

The story of how Caribou Biosciences developed a hybrid RNA-DNA guide to increase Cas9 specificity.

Discovery & Development Drug Delivery

At First Sight

| Jamie Irvine | 13 min read

Three companies – Cardinal Health, REGENXBIO, and Beacon Therapeutics – help us explore gene therapy development in the ophthalmic space

Business & Regulation Trends & Forecasts

Bridging the Gap

| Jamie Irvine | 7 min read

What have we learned from an ever-evolving cell and gene therapy field?

Manufacture Advanced Medicine

What’s Happening with CAR T Therapies?

| Stephanie Vine | 3 min read

A look at the FDA’s safety investigation into CAR T therapeutics.

Manufacture Advanced Medicine

Format and Function: Optimizing Gene Therapy Manufacturing Workflow

| Elpidia Gamez | 4 min read

Gene therapy has the potential to transform lives, but promising treatments for a wide range of diseases require optimal cell culture media solutions

Manufacture Advanced Medicine

The World’s First CRISPR-Based Therapeutic Approval

| Stephanie Vine | 3 min read

It’s official: CRISPR medicines are here as UK authorizes exa-cel.

Manufacture Advanced Medicine

Cell yourself

| Molly Mjolsness | 5 min read

Navigating the cell therapy partnership selection process can be complex. Here, I share the questions you should be asking to help you get it right.

Business & Regulation Trends & Forecasts

Top Cell & Gene Prospects

| Jamie Irvine | 6 min read

Experts discuss the most promising growth prospects in the cell and gene landscape

Discovery & Development Drug Discovery

Afraid of Banality, Driven by Beauty

| 5 min read

Sitting Down With … Tirtha Chakraborty, Chief Scientific Officer at Vor Bio

Manufacture Advanced Medicine

Video: Josh Ludwig Talks Manufacturing in the Cell and Gene Industry

| Jamie Irvine

We interviewed ScaleReady’s Global Commercial Director Josh Ludwig to learn more about manufacturing in the Cell and Gene Industry

Manufacture Advanced Medicine

Manipulating the Fabric of Life

| 20 min read

A selection of experts using genome editing and CRISPR/Cas9 for drug development purposes offer their views on the field.

Discovery & Development Drug Discovery

Big Problem, Mini Solution

| Jamie Irvine | 6 min read

Researchers have designed a “mini gene” therapy that could hold promise for treating Usher Syndrome Type 1F

Webinar

Sponsored by Bio-Rad Laboratories

ddPCR: A Driving Force for Innovation in Gene Therapy Manufacturing and Quality Assurance

Join us to learn about the latest innovations in ddPCR and how they can help you bring new and safe gene therapies to market faster!

Watch On-Demand

Manufacture Advanced Medicine

Unstoppable

| 5 min read

Sitting Down With… Sheila Mikhail, CEO and co-founder, AskBio; founder, Columbus Children’s Foundation.

Discovery & Development Advanced Medicine

Video: Angela Osborne Discusses the Latest Cell and Gene Industry Trends

| Stephanie Vine

Check out our latest video interview with Angela Osborne who discusses the latest cell and gene industry trends.

Discovery & Development Formulation

T Cell Bright Spark

| 3 min read

An insight into the research fuelling developments for universal cancer immunotherapies

Manufacture Advanced Medicine

Roundtable Discussion: Priorities for the Cell and Gene Field

| Stephanie Vine

Three experts give their views on the state of play in cell and gene manufacturing, and the challenges that lie ahead

Manufacture Advanced Medicine

Standardize for Success

| Mark Sawicki | 4 min read

High growth predictions for regenerative medicine are exciting, but what if current capacity can’t keep pace?

Manufacture Advanced Medicine

Stem Cells: The Next (Re)generation

| Rob Coker | 4 min read

CellProthera is demonstrating the safety and efficacy of a cell therapy approach to regenerating tissue following myocardial infarction

Manufacture Advanced Medicine

Video: Ivan Wall Speaks Out About Cell and Gene Training

| Stephanie Vine

A video interview addressing the need for training in cell and gene therapy manufacturing.

Manufacture Advanced Medicine

Titan on the Horizon

| Angus Stewart | 6 min read

Can digital tools help cell and gene therapy evolve?

Manufacture Advanced Medicine

A Patient Story In The UK

| Stephanie Vine | 2 min read

Libmeldy gene therapy is used for the first time in the UK outside of a clinical trial.

Business & Regulation Trends & Forecasts

Weathering the Storm: Cell and Gene’s Economic Downturn

| James Wilson, Anshul Mangal | 5 min read

An early wave of investor enthusiasm followed by an economic crisis has landed our field in a sea of trouble – so how can we swim to shore?

Manufacture Advanced Medicine

Cell and Gene: Generating the Next Generation

| Angus Stewart | 4 min read

What can cell and gene do to avoid a seemingly inevitable rush on supporting products and services?

Business & Regulation Business Practice

Between Two Worlds: Doing Business as a Cell and Gene Academic

| Stuart Curbishley | 6 min read

Pharma depends on academia, but that relationship can become better… and more fluid

Manufacture Advanced Medicine

Advanced – But Not Advanced Enough

| Brian Mullan | 12 min read

Great successes are being seen in gene therapy, but there are still gaps in our scientific knowledge – and our manufacturing prowess.

Business & Regulation Trends & Forecasts

Video Roundtable: Cell & Gene in a World in Turmoil

| Angus Stewart

In the face of economic uncertainty in a post-pandemic world, how will the cell and gene field respond?

Manufacture Advanced Medicine

Less Than 5 Percent Human Effort: Thoughts on the Role of Automation on Cell and Gene Therapy

| Dalip Sethi | 7 min read

We all know that automation can reduce human labor, but how else can it make economically viable cell and gene therapies a reality?

Manufacture Advanced Medicine

Cell and Ex Vivo Gene Therapies: A Manufacturing Odyssey

| George Todorov | 17 min read

Demand for cell and gene therapies is increasing, but are current manufacturing approaches up to the task?

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