A Goal in MiNDS
An implantable neural device can deliver drugs to the brain with pinpoint accuracy
James Strachan |
A team of researchers from MIT have taken the first steps towards the development of a needle that can deliver drugs to specific parts of the brain (1) – potentially reducing the off-target effects that come with drugs used to treat neurodegenerative conditions. The researchers tested the device – which they call MiNDS – in mice and a rhesus macaque monkey. The results showed that the device could deliver drugs selectively to small deep-brain structures in a controlled manner.
Positron emission tomography imaging showed localized drug delivery with a volume of ~1-mm^3. “This is essential, given that many key neural circuit nodes have such small volumes,” says Canan Dagdeviren, assistant professor at MIT and lead author of the study.
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