A Sniff of Success for Small Particles
By Ramesh Raliya
Ramesh Raliya |
Both the pharma industry and the research community have been investigating enhanced drug delivery to the brain for many years, but despite the time, effort and costs invested in this field, getting drugs to the brain continues to be a significant challenge. Historically, drug delivery to the brain relied either on intracerebral injections or on temporary disruption of the tight junctions of the blood-brain barrier; for example, with high-osmolar solutions. These approaches, however, feature a number of limitations, including invasiveness, tissue damage, and uncontrolled distribution of the drug after delivery. Could these drawbacks be avoided by delivering drugs via the nose? After all, the simplest and shortest path for airborne nanoparticles to reach the central nervous system is through the olfactory tract; once drugs permeate the nasal epithelium, they travel directly to the brain along olfactory nerves.
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