Cookies

Like most websites The Medicine Maker uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Discovery & Development Drug Delivery, Drug Discovery, Ingredients

Breathing New Life into Existing Drugs

Finding new uses for old drugs is now a significant trend in the pharma industry. There can be some inconsistency about terminology, but generally speaking, a repurposing project will take a drug already approved for one indication and seek approval for another or, alternatively, a new formulation may be created to allow administration via a different route for the same indication. A repositioning project, meanwhile, tends to take an existing drug and give it an improved or altered product profile, while keeping the same administration route. Either way, as well as providing advantages for patients, repurposing or repositioning can also be used to extend intellectual property (IP) coverage and drive additional revenue for innovators. Drug repositioning now accounts for almost a third of all new drug products, generating half a trillion dollars in annual sales across all dosage forms (1).

Inhaled administration offers significant repurposing opportunities; only a relatively small number of medicines made their first appearance on the market in inhaled form. A number of drugs that are today very familiar in inhalers started life in another delivery format, including beta-2 agonists, anticholinergics, and corticosteroids, as well as antibiotics, such as tobramycin and aztreonam. Though most are locally effective products – notably those designed to treat respiratory disease – some are systemically targeted, such as drugs to treat diabetes, migraine, or Parkinson’s disease.

Read the full article now

Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE!

Login

Or register now - it’s free!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

When you click “Register” we will email you a link, which you must click to verify the email address above and activate your account. If you do not receive this email, please contact us at [email protected].

About the Author

Geraldine Venthoye

Executive Vice President – Product Development at Vectura

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

Register