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Discovery & Development Business Practice, Formulation, Trends & Forecasts

Evaluating the rheological properties of hyaluronic acid hydrogels for dermal filler applications


Hyaluronic acid (HA) is a naturally occurring polysaccharide frequently used as a functional ingredient in many topical and subcutaneous anti-ageing treatments such as dermal fillers, which exploit the polymer’s unique viscoelastic properties for effective soft tissue augmentation. When administered subcutaneously, HA builds an elastic network within wrinkles and rhytides to give the skin a plumper and fuller look. Naturally occurring HA has a half-life of less than three days so increasing the durability of the polymer is essential to developing products with greater clinical persistence and an acceptable shelf life. Increasing both the molecular weight (MW) and degree of cross-linking of the polymer is a proven strategy for improving mechanical strength and extending degradation times. However, these characteristics also impact other properties of the HA such as viscosity and viscoelasticity.

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