Fungal (Library) Growth
Time to mine the biologically active compounds of fungi
Maryam Mahdi | | Quick Read
Thousands of biologically active secondary metabolites derived from different types of fungi have been analyzed and assigned to a library in a joint effort between the Hubrecht Institute, the Westerdijk Fungal Biodiversity Institute and Utrecht University in the Netherlands.
“An aging global population and the growing issue of drug resistance means that we need better and newer drugs, but the number of chemically distinct compounds that are being used in prescription drugs is limited. In addition, the active compounds in these drugs are often chemically related, relying on similar mechanisms to function,” explains research leader, Jeroen den Hertog from the Hubrecht Institute. “Fungi are known to produce pharmaceutically relevant compounds. And despite there being an estimated two million species of fungi, only a small fraction has been analyzed for their expression of biologically active compounds to date.”
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