Recycled and reused: scientists develop a library to help teach old drugs new tricks.
Maryam Mahdi |
In sunny San Diego lies a library of drugs, which researchers are encouraging companies to exploit to repurpose old drugs for new needs. The open access drug catalog, ReFRAME, consists almost entirely of small molecules – all of which have reached the clinical development stage or undergone thorough preclinical filing – and is already showing results. Two compounds from the library have been identified as suitable treatments for tuberculosis and Cryptosporidium spp (1).
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- J Janes et al., “The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis,” PNAS 115, 10750-10755 (2018).