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Discovery & Development Drug Discovery, Small Molecules

Slowing the Pace of Parkinson’s

This article was published in our sister publication, The Small Molecule Manufacturer, which celebrates the field of small molecule drug development and manufacturing with interviews and articles focusing on success stories, equipment, and new processing techniques. Read more about The Small Molecule Manufacturer here https://themedicinemaker.com/manufacture/small-but-never-forgotten

A team, led by Matthew Disney from Scripps Research and M. Maral Mouradian from the Rutgers Robert Wood Johnson Medical School Institute for Neurological Therapeutics, has developed a small molecule drug, dubbed Synucleozid, which targets the messenger RNA (mRNA) of ɑ-synuclein, a protein whose misfolding is genetically and neuropathologically linked to Parkinson’s disease (PD) (1). Though there are several experimental treatments in development that target ɑ-synuclein protein aggregates, the team’s goal is to prevent them from developing entirely by inhibiting its translation at the mRNA stage.

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About the Author

Maryam Mahdi

Associate Editor

After finishing my degree, I envisioned a career in science communications. However, life took an unexpected turn and I ended up teaching abroad. Though the experience was amazing and I learned a great deal from it, I jumped at the opportunity to work for Texere. I'm excited to see where this new journey takes me!

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