The big reveal: Workhorse + Innovation = more information (Part 2)
In this second article of a short series Dr Paul Kippax is looking at how recent innovations are substantially enhancing the value and informational productivity of some of our established and trusted analytical techniques. This time, the addition of multiple detectors to a GPC/SEC analysis…
The established technique: Gel permeation/size exclusion chromatography
For those working with materials with a chain-like molecular structure, such as proteins and polymers, gel permeation chromatography (GPC) or size exclusion chromatography (SEC) (alternative names for the same technique) is an essential tool. GPC/SEC is used to determine the molecular weight (MW) and molecular weight distribution of such samples, parameters that define performance. By altering MW, a polymer scientist can control material properties such as hardness, gas permeability and melting point; a food scientist can change the thickening or gelling behavior of a polysaccharide; and a biopharmaceutical formulator can determine the stability of a therapeutic protein.
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