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Discovery & Development Clinical Trials, Drug Delivery, Formulation

The big reveal: Workhorse + Innovation = more information (Part 2)

The established technique: Gel permeation/size exclusion chromatography

For those working with materials with a chain-like molecular structure, such as proteins and polymers, gel permeation chromatography (GPC) or size exclusion chromatography (SEC) (alternative names for the same technique) is an essential tool.  GPC/SEC is used to determine the molecular weight (MW) and molecular weight distribution of such samples, parameters that define performance. By altering MW, a polymer scientist can control material properties such as hardness, gas permeability and melting point; a food scientist can change the thickening or gelling behavior of a polysaccharide; and a biopharmaceutical formulator can determine the stability of a therapeutic protein.

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