The Good, The Bad, and The Side Effects
Can drugs be modified to eliminate their adverse effects?
Maryam Mahdi | | Quick Read
Using simulations, researchers believe they can reduce the side effects of G protein-coupled receptor-targeting (GPCR-targeting) drugs (1). The aim is to design new drugs that alter the shape of these receptors in ways that activate beneficial signaling pathways but inhibit harmful signaling pathways.
“GPCRs represent the largest class of drug targets. In a phenomenon known as biased signaling, different drug molecules that bind to the same GPCR trigger distinct intracellular signaling pathways,” says Carl-Mikael Suomivuori, a postdoctoral research fellow at Stanford University. “A drug can, therefore, bind to a GPCR and activate signaling pathways with beneficial effects for the patient while avoiding pathways that cause harmful side effects.”
Investigating how this dual action could be exploited, Suomivuori and his colleagues ran molecular simulations of the angiotensin II type 1 receptor, a typical GPCR and a cardiovascular drug target. Their simulations revealed that, when bound to different drug molecules, the receptor adopted distinct conformations that made it more likely to interact with certain intracellular signaling proteins over others.
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