The Next (Air)Wave of Inhalables
The inhaler is an important drug delivery device, but for the technology to evolve, questions about efficacy must be answered.
David Lewis |
Since they were first developed in the 1950s, advances in inhaler drug delivery technology have been substantial. But compared with tablets, the technology it still in its infancy. Inhaled drugs are delivered directly to the target tissue where they can act immediately, in contrast to systemic delivery methods. This localized delivery is a widely recognized benefit of inhalables, as a lower dose is generally needed to achieve therapeutic effect. Since their initial design, inhaler devices and formulations have undergone rapid innovations; most notably the introduction of hydrofluoroalkane as a propellant in metered dose inhalers, which improved the degree of drug deposition in the lung. Despite this, more improvements in inhaled delivery methods are required to further increase the drug dose reaching the lung by manipulating particle properties and therefore improving the treatment of prevalent respiratory diseases, such as chronic obstructive pulmonary disease.
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