Biologically Active Excipients?
Uncovering the truth about “inert” ingredients
Maryam Mahdi | | Quick Read
Are APIs the only drug ingredients with biological activity? That’s certainly the case for the vast majority of formulations, but new research suggests that a notable minority of excipients aren’t quite as inert as previously thought (1). Brian Shoichet, a professor at the University of California, San Francisco (UCSF), explains that his study identified 38 ingredients with potent activity against specific receptors and enzymes in vitro. A surprising result – but not entirely unexpected; Shoichet says he realized several years ago that something was amiss with the “inactive” ingredients included in many drugs.
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