Click and Connect
Click chemistry creates biocompatible hydrogels for drug delivery and tissue engineering
Alginate hydrogels have great potential for controlled release because the rate at which they degrade can be fine-tuned by researchers. However, the reagents generally used to produce these polymers are not fully chemoselective – they can cross-react with, and potentially damage, the cells or drugs being encapsulated in the gel.
To harness the potential for clinical use, two labs at Harvard and the Wyss Institute has been working on the development of a true biocompatible alginate hydrogel using simple ‘click chemistry’ (1).
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