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Manufacture Bioprocessing - Upstream & Downstream

Editing for Purity

When CHO cells are used to produce recombinant-protein drugs, they can also produce many other unwanted proteins. Although these are removed during purification, they add to manufacturing costs and reduce efficiency. Researchers at the University of California, San Diego, and the Technical University of Denmark have published a paper showing how they used “multiplex secretome engineering” to increase recombinant protein production and purity (1).

The work builds on prior computational work showing that a relatively small number of unwanted proteins account for the majority of cell energy and resources (1). This inspired the researchers to eliminate the dominant contaminating proteins to free up cellular resources.

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  1. S Kol at al., “Multiplex secretome engineering enhances recombinant protein production and purity,” Nature Communications, 11 (2020).
About the Author
Stephanie Vine

Making great scientific magazines isn’t just about delivering knowledge and high quality content; it’s also about packaging these in the right words to ensure that someone is truly inspired by a topic. My passion is ensuring that our authors’ expertise is presented as a seamless and enjoyable reading experience, whether in print, in digital or on social media. I’ve spent fourteen years writing and editing features for scientific and manufacturing publications, and in making this content engaging and accessible without sacrificing its scientific integrity. There is nothing better than a magazine with great content that feels great to read.

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