Enhancing Endocannabinoid Signaling
What does the endocannabinoid system mean for drug discovery and development?
Alan Ezekowitz |
The endocannabinoid system is a signaling network in the brain and periphery that plays a role in maintaining the balance of many of our physiological functions, including sleep, appetite, pain, memory, and mood. The system is also the target of the psychoactive substance in the cannabis plant, tetrahydrocannabinol (THC), which produces its effects through activation of two cannabinoid receptors, CB1 and CB2. In the brain, CB1 activation reduces excessive neurotransmission, while CB2 activation reduces inflammatory signaling. The naturally occurring activators of the cannabinoid receptors are the endogenous cannabinoids, or endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG).
Enjoy our FREE content!
Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE and always will be!
Login if you already created an account
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Medicine Maker magazine