Enhancing Endocannabinoid Signaling
What does the endocannabinoid system mean for drug discovery and development?
Alan Ezekowitz |
The endocannabinoid system is a signaling network in the brain and periphery that plays a role in maintaining the balance of many of our physiological functions, including sleep, appetite, pain, memory, and mood. The system is also the target of the psychoactive substance in the cannabis plant, tetrahydrocannabinol (THC), which produces its effects through activation of two cannabinoid receptors, CB1 and CB2. In the brain, CB1 activation reduces excessive neurotransmission, while CB2 activation reduces inflammatory signaling. The naturally occurring activators of the cannabinoid receptors are the endogenous cannabinoids, or endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG).
Read the full article now
Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Medicine Maker magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.