Cookies

Like most websites The Medicine Maker uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Manufacture Bioprocessing - Upstream & Downstream

How to Beat the Bottleneck

sponsored by GE Healthcare

The monoclonal antibody (mAb) field has come a long way since the first therapeutic mAb was commercialized in 1986. As of today, over 60 mAbs have been approved in the US and Europe and sales of mAbs are expected to cross $125 billion by 2020 (1). As the number of mAbs on the market and in development has accelerated over the years, so too have upstream titers. With the increasing upstream titers, the constraints on downstream processing have only increased. The efficient recovery and purification of mAbs from cell culture medium is a critical part of the production process and can contribute significantly to the total manufacturing costs (2). Protein A affinity chromatography is commonly used in the process-scale purification of mAbs because it is an easy, fast and selective procedure for capturing the target protein – often resulting in a greater than 99 percent purity from complex cell culture media in a single step.

The demands of protein A resins have evolved significantly over the years and the nature of the process means that the capture step can act as a bottleneck – especially as upstream titers continue to increase. I believe suppliers must do what they can to keep pace with the constantly evolving demands of the industry. And this is why GE Healthcare Life Sciences has made the long-term strategic decision to constantly improve our protein A chromatography resins.

Read the full article now

Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

Register