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Manufacture Bioprocessing - Upstream & Downstream

Process Intensification: Getting More From Less

sponsored by ThermoFisher Scientific

It’s no secret that the biopharmaceutical industry is under intense pressure to reduce costs – especially in manufacturing – and getting more output from a given process is a clear win. Process intensification does just that. It can take an existing process and optimize it to increase output: more product in a shorter time, with fewer steps, and from a smaller working footprint. Process simplification, on the other hand, focuses on streamlining activities to increase efficiencies.

Which option is best: intensification or simplification? It ultimately depends on the type of molecule you’re making, the current manufacturing challenges and bottlenecks you’re facing, and the stage of development your product is in.  Process changes can occur at any stage during development, even post-launch, and the better characterized your existing process and product are, the easier it will be to evaluate the impact to the critical quality attributes of your product and implement changes (1).

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About the Author

Serena Fries Smith

Serena Smith is Director of Strategic Customer Engagements at Thermo Fisher Scientific.

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