Biohybrid micromotor drug delivery for gynecological cancers
William Aryitey |
When tackling the challenges of drug delivery, new tools are always welcome. And in certain special cases, nature has already solved some of the problems encountered...
“We considered sperm a potential candidate to carry drugs, especially in female reproductive tracts, because of their adapted ability to swim in,” says Mariana Medina-Sánchez leader of the Micro and Nanobiomedical Engineering Group at IFW Dresden and coauthor of the study uploaded to pre-print server arXiv (1). “Additionally, sperm have the ability to encapsulate hydrophilic drugs [...] their bodies protect the drugs from body dilution, immunoreactions, and enzyme degradation. And with their somatic cell-fusion ability and such a compact membrane system, sperm can release drugs inside cancer cells while efficiently avoiding dose dumping.”
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