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Manufacture Small Molecules, Technology and Equipment, Facilities, Dosage Forms, Process Control

Wet, Wet, Wet

This article was originally published in our sister publication, The Small Molecule Manufacturer, in July 2019. 

Read more about The Small Molecule Manufacturer here.

In the UK, CPI is collaborating with GlaxoSmithKline and AstraZeneca to establish a small-scale continuous wet granulation manufacturing facility for oral solid dosage forms. The facility is due to be completed in Q3 2020 and will be available as a national, open-access centre for contract development. The facility is part of a project called PROSPECT CP (Proving Real-world Scalable Predictive Tools/Technologies for Complex Particles).

“One of CPI’s strategic themes is predictive design and manufacturability, which includes exploring the use of PAT-enabled, model-based process control to help speed the adoption of digital manufacturing technologies across the whole formulation industry,” says Jacquin Wilford-Brown, Principal Scientist at CPI. “PROSPECT CP is one component of this, seeking to create a facility to remove risks and barriers, and speed up development of new solid products. The initial demonstrator is in the pharmaceutical space, building on our previous work and linking forward to the Medicines Manufacturing Innovation Centre.”

Tablets remain the most prevalent drug delivery method and wet granulation is often used for APIs with challenging processing properties, as some molecules are simply not amenable to direct compression approaches. In recent years, CPI has noted that more and more pharma companies are expressing interest in continuous technologies. Given that the UK Medicines Manufacturing Innovation Centre is running a project focused on direct compression, it made sense for CPI and its partners to look at twin-screw wet granulation.

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About the Author

Stephanie Sutton

Making great scientific magazines isn’t just about delivering knowledge and high quality content; it’s also about packaging these in the right words to ensure that someone is truly inspired by a topic. My passion is ensuring that our authors’ expertise is presented as a seamless and enjoyable reading experience, whether in print, in digital or on social media. I’ve spent seven years writing and editing features for scientific and manufacturing publications, and in making this content engaging and accessible without sacrificing its scientific integrity. There is nothing better than a magazine with great content that feels great to read.

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