Subscribe to Newsletter
Discovery & Development Clinical Trials, Small Molecules

A Weighty Loss

A trial of Novo Nordisk’s semaglutide involving 1,961 obese patients has shown that the drug can help cut body weight. Three-quarters of patients receiving semaglutide lost more than 10 percent of their body weight, and over one-third lost more than 20 percent (1). Patients also showed improvement in cardiometabolic risk factors and a greater increase in self-reported physical functioning compared with placebo. The drug works by interfering with the brain’s appetite-regulating system, leading to reduced hunger and calorie intake.

One of the principal authors of the paper, Rachel Batterham, Professor of Obesity, Diabetes and Endocrinology at University College London, UK, said, “No other drug has come close to producing this level of weight loss – this really is a game changer. For the first time, people can achieve through drugs what was only possible through weight-loss surgery (2).”

Semaglutide is already approved as a treatment for type 2 diabetes in numerous countries, but Novo Nordisk has also filed for FDA and EMA approval to use the drug in weight management.

Receive content, products, events as well as relevant industry updates from The Medicine Maker and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. JPH Wilding et al., NEJM (2021). DOI: 10.1056/NEJMoa2032183.
  2. UCL (2021). Available at
About the Author
Stephanie Vine

Making great scientific magazines isn’t just about delivering knowledge and high quality content; it’s also about packaging these in the right words to ensure that someone is truly inspired by a topic. My passion is ensuring that our authors’ expertise is presented as a seamless and enjoyable reading experience, whether in print, in digital or on social media. I’ve spent fourteen years writing and editing features for scientific and manufacturing publications, and in making this content engaging and accessible without sacrificing its scientific integrity. There is nothing better than a magazine with great content that feels great to read.

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine