Subscribe to Newsletter
Discovery & Development Drug Discovery, Drug Delivery

Closer to the Boundary

Of all drugs capable of crossing the cell membranes, most are too small to affect intracellular protein–protein interactions (PPIs) – but new research published in the Journal of Medicinal Chemistry could help change this. Led by Jiwon Seo, an associate professor at Gwangju Institute of Science and Technology, Republic of Korea, a team of scientists have found that a peptide, cyclosporin O (CsO), could help produce medicines capable of crossing cell membranes and interfering with PPIs.

Seo’s team investigated various properties of CsO and its derivatives and compared them with cyclosporin A (CsA), a similarly promising, but flawed, candidate for membrane-crossing, PPI-disrupting medicine. They found that CsO did not cross membranes as effectively as CsA, but outperformed CsA in terms of pharmacokinetic profile and plasma concentration.

Although further study will be necessary, Seo remains optimistic that his team’s work could open up new avenues for tackling undruggable targets including cancer, neurodegenerative disorders, and metabolic diseases.

See also:a poster from the GIST that breaks down the science beind the research

Receive content, products, events as well as relevant industry updates from The Medicine Maker and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

About the Author
Angus Stewart

Associate Editor of The Medicine Maker

Between studying for my English undergrad and Publishing master's degrees I was out in Shanghai, teaching, learning, and getting extremely lost. Now I'm expanding my mind down a rather different rabbit hole: the pharmaceutical industry. Outside of this job I read mountains of fiction and philosophy, and I must say, it's very hard to tell who's sharper: the literati, or the medicine makers.

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine