Cookies

Like most websites The Medicine Maker uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Discovery & Development Drug Discovery, Business Practice, Advanced Medicine

Diabetes: Finding a Panacea

In 2013, world leaders came together to develop an action plan to address the global rise in noncommunicable diseases (1). Among the goals was to prevent further increases in the number of cases of diabetes mellitus (types 1 and 2). But adequately addressing the current epidemiological situation is a challenge; over 400 million people worldwide live with diabetes (5-10 percent of individuals live with type 1) and estimates suggest that the number will continue to rise (2,3). The high disease burden has placed significant stress on countries’ economic and healthcare infrastructure.

According to Kiran Mazumdar-Shaw, Founder and Executive Chairperson of Biocon, ensuring proper disease management is crucial to curbing this global healthcare problem. “Diabetes is often described as a disease of halves – only half of the people living with it get diagnosed; only half this group receive treatment; and, among this group, only half are compliant with their medication,” she says. “Although early insulinization is regarded as an efficient aid to improve long-term control and the quality of patient lives, this method of treatment fails to address certain problems.” Needle anxiety and issues related to cold chain supply, particularly in rural areas of developing countries, may delay the onset of treatment, she adds – problems exacerbated by the stunted growth of the treatment pipeline.

“Insulin has been used as a life-saving treatment for close to 100 years,” says Stephan Kissler, Associate Professor of Medicine at Harvard Medical School. “Though the types of insulin preparations available have continuously improved, as have methods of administering them – with smaller needles, insulin pens, and automated pumps available today – we still don’t have a treatment to prevent or cure diabetes.”

This leaves the door for innovation wide open. But before new options can be developed, Mazumdar-Shaw believes that the pharmaceutical industry can do more to improve access to existing treatments.

The immunotherapy approach

According to Kissler, researchers have spent decades trying to understand type 1 diabetes and devise effective therapies. “In recent years, the field has recognized that, instead of solely targeting the immune system that causes the destruction of insulin-producing cells, an alternative approach might be to protect these cells from the immune system instead. This is a relatively new strategy that holds much promise,” he says.

According to Kissler, researchers have spent decades trying to understand type 1 diabetes and devise effective therapies. “In recent years, the field has recognized that, instead of solely targeting the immune system that causes the destruction of insulin-producing cells, an alternative approach might be to protect these cells from the immune system instead. This is a relatively new strategy that holds much promise,” he says.

For Lucy Walker, Professor of Immune Regulation at University College London, immunotherapy may hold the key to tackling type 1 diabetes. Leading a team of researchers, she has begun to investigate how existing immunosuppressive therapies can be applied to the disease. “Immunotherapy has completely changed the landscape of cancer care and I am really excited to see it starting to come to the fore in autoimmunity,” she says. “There are, understandably, more barriers to testing new therapies in people with type 1 diabetes, who are often young and otherwise healthy, than in people with advanced cancer. However, recent studies show that T cell-directed immunotherapy could delay the development of the condition by two years.” Last year, the EMA awarded Priority Medicines designation to teplizumab – a drug that binds to the proinflammatory T cell co-receptor CD3, preventing it from killing insulin-producing cells. It also received a breakthrough designation from the FDA. The drug was shown to slow the onset of type 1 diabetes in at-risk patients by two to three years (4). The potential of this therapy, coupled with other recent results, has been a source of inspiration for Walker, whose work on abatacept – an immunosuppressive drug – could help treat the condition. In 2014, she found that T follicular helper cells were partly responsible for the destruction of the pancreatic beta cells that produce insulin. Now, in a project funded by Diabetes UK and AstraZeneca, Walker is exploring the role of abatacept in reducing T follicular helper cell numbers and thereby protecting insulin-producing cells. So far, the drug – currently used to treat rheumatoid arthritis – has been shown to help some people with type 1 diabetes, but not others, but the study must be expanded for its full potential to be realized.

High-quality research takes time and, therefore, requires consistent funding to help move it forward

Walker’s work is just one example of the innovative research taking place to help people living with diabetes; many others are working on new treatments. Researchers at Texas A&M University’s College of Medicine, for example, have reported on an immunotherapy that was shown to reduce inflammation and halt immune attacks on beta cells (5).

The Type 1 Diabetes UK Immunotherapy Consortium is also conducting several trials to investigate the potential of immunotherapies. This includes the USTEKID Phase II trial, which is investigating whether ustekinumab – a drug first produced by Janssen to treat psoriasis – will be effective in preventing pancreatic damage (6).

Other research teams are approaching the problem by using currently available small molecules to their advantage. “Repurposing an old drug that is off-patent has the benefit of potentially making a very cheap drug available to patients,” Kissler says. “Because a repurposed drug does not have to undergo lengthy preclinical development and the many stages of toxicity and safety testing, its cost can remain low.”

Though scientists have developed methods of creating insulin-producing cells by resetting the pluripotency of blood and skin cells – allowing them to be converted into pancreatic beta cells – the risk of their destruction by the immune system still remains. With this in mind, Kissler and his colleague Peng Yi at the Joslin Diabetes Center are investigating how a drug first developed in the 1950s could prevent the autoimmune killing of beta cells.

Using a genetic screening approach, the researchers discovered an enzyme, renalase, that had previously been associated with the risk of type 1 diabetes, but whose function in disease was unknown. They found that the enzyme modifies beta cells’ ability to withstand cellular stress and autoimmune killing (7).

“We went on to search for a small molecule that could inhibit renalase function to mimic the protection we observed in cells whose RNLS gene we had inactivated with a mutation,” Kissler says.  “This search yielded the drug pargyline, which was developed as a treatment for hypertension. Although it is no longer being made, the patent has long since expired, which should make it inexpensive to produce.” The team now plan to test the drug in newly diagnosed diabetic patients but, because this drug and others like it are not specifically designed to treat diabetes, questions arise as to the challenges associated with their use.

“Because the drug was originally designed for a different purpose – in this case, the treatment of hypertension – one has to make sure that the original effect of the drug does not pose a safety issue for the new application of the drug,” Kissler says.

In the years to come

Whether companies and researchers are pursuing new drugs or repurposing old ones, funding is still vital. Walker says that sustained funding – particularly for those in academic environments – is crucial to making headway in diabetes research.

“High-quality research takes time and, therefore, requires consistent funding to help move it forward,” she says. “I have been lucky to have received long-term support, enabling me to build a sustainable program of work. Ultimately, there is a human capital that goes into making research findings and it would be hugely satisfying to  take this project to the point where people can benefit.”

Although new therapeutic solutions will help inform the future landscape of diabetes management, Mazumdar-Shaw believes that digital therapeutics will also help “achieve optimal outcomes for diabetic patients.” These software-driven interventions are currently used across a variety of disease indications to help patients manage the conditions they live with. She says, “Digital therapeutics will emerge as part of the new standard of care for diabetes. By pairing insulin with a digital solution we hope to improve treatment outcomes thus lowering the chances of patients developing co-morbidities, which will reduce costs to healthcare systems in the long term.” 

The biggest question of all, however, is: will a cure for diabetes be found in our lifetimes? Kissler is optimistic. “It’s definitely possible. We all look forward to working on this with optimism, knowing that there may be failures and challenges ahead, but hoping that we can help cure all forms of diabetes as well as their complications.”

The price of good health

In recent years, debates about the price of insulin have swirled around industry spheres. Though a necessary treatment for all type 1 and some type 2 diabetic patients, the cost of the drug has continued to rise. In the US, for example, a single vial of insulin can cost US$250, preventing the most vulnerable from accessing it (8). “The lack of equitable access to affordable insulin remains a key impediment to successful treatment and results in comorbid complications and premature deaths,” Mazumdar-Shaw says. “Not only are people with diabetes in low- and middle-income countries struggling to manage their condition, but even those in developed markets are forced to ration insulin due to its high cost. It is an untenable situation because, despite being universally available for nearly a century, insulin is yet to be universally accessible.”

Insulin-dependent diabetes patients have to contend with a large price differential between recombinant human (rh-) insulin formulations that tend to be more affordable and pricier insulin analog formulations. Insulin analogs are genetically engineered to produce either long-acting or rapid-acting forms of the drug. They differ from rh-insulin in that more changes are made to their amino acids to allow for their faster or prolonged action in the body.

“The increasing use of insulin analogs compared with rh-insulin in the recent past – especially in the developed world – has meant that many are forced to choose between going into debt or cutting back on medication,” she continues.  So, with these difficult decisions to make, what can the industry do to better support patients?

For Biocon, the answer lies in creating solutions for emerging and developing markets. “Using our proprietary platform technology that relies on Pichia pastoris – a yeast species – we can manufacture cost-effective rh-insulin and insulin analogs,” says Mazumdar-Shaw. This proprietary technology offers an efficient and optimized process for manufacturing insulin.

And though companies are proving that they are committed to positively impacting patient lives, there is still more that can be done to ensure therapies are affordable and accessible. Time will be the determining factor in seeing real change.

Enjoy our FREE content!

Log in or register to gain full unlimited access to all content on the The Medicine Maker site. It’s FREE!

Login

Or register now - it’s free!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

When you click “Register” we will email you a link, which you must click to verify the email address above and activate your account. If you do not receive this email, please contact us at [email protected].

  1. WHO, “Global Action Plan for the Prevention and Control of NCDs 2013-2020” (2013). Available at https://bit.ly/2IZ6Eqm.
  2. Diabetes UK, “Facts and Figures” (2020). Available at https://bit.ly/34vKdBm.
  3. WR Rowley, “Diabetes 2030: Insights from Yesterday, Today, and Future Trends,” Popul Health Manag, 20, 6 (2017).
  4. JDRF, “New Findings from Groundbreaking Study Shows Extended Delay in Onset of Type 1 Diabetes” (2020). Available at https://bit.ly/34tWjv1.
  5. M Haque et al., “Stem cell–derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes,” JCI Insight, 4,7 (2019).
  6. T1D Immunotherapy Consortium, “USTEKID Study” (2020). Available at https://bit.ly/3kBZBSB
  7. EP Cai et al., “Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes,” Nat Metab, 2, 934 (2020).
  8. Singlecare, “Insulin prices: How much does insulin cost?” (2020). Available at https://bit.ly/3kHYCjy

About the Author

Maryam Mahdi

Associate Editor

After finishing my degree, I envisioned a career in science communications. However, life took an unexpected turn and I ended up teaching abroad. Though the experience was amazing and I learned a great deal from it, I jumped at the opportunity to work for Texere. I'm excited to see where this new journey takes me!

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

Register