Eliminating Side Effects In Silico
Next-generation pain medications developed with computer simulations could improve on current opioid offerings
Roisin McGuigan |
“My group has studied the biology and pharmacology of opioid receptors on peripheral sensory neurons for over 25 years”, says Christoph Stein, Director, Department of Anesthesiology and Surgical Intensive Care Medicine, Charité – Universitätsmedizin Berlin. “Our aim has always been to find mechanisms and opioid receptor ligands that can be developed into drugs which inhibit pain, without also eliciting typical adverse effects of conventional opioids, such as apnea, addiction, sedation or constipation.”
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