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Discovery & Development Formulation

How Does it Feel?

When my colleagues and I are considering a new dermatological formulation, we focus on four areas: solubility, stability, sensory and delivery. We ensure that the API is at least partially soluble in the formulation and stable physically and chemically. We also consider whether the patient will actually apply the formulation and ensure that the active pharmaceutical ingredient (API) can reach the required target.

The pharmaceutical industry puts a huge amount of resource into the solubility, stability and delivery aspects of derma formulation, but the sensory aspect is something that is largely overlooked, if not ignored altogether. Is it really right to leave the aesthetics of a formulation to an afterthought?

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About the Author

James Humphrey

James Humphrey is a Market Applications Specialist working in the research laboratories of Croda in the UK. He focuses on what excipients can do to improve pharmaceutical formulations, whether it’s enhancing bioavailability, stability or aesthetics. James says, “What I love about formulation is the neverending challenge of working out how seemingly small and insignificant changes to a formulation result in massive variation in performance.”

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