How Does it Feel?
When it comes to topical formulations, I firmly believe that patients care about the way a cream or ointment feels – and that it plays a very important role in compliance.
James Humphrey |
When my colleagues and I are considering a new dermatological formulation, we focus on four areas: solubility, stability, sensory and delivery. We ensure that the API is at least partially soluble in the formulation and stable physically and chemically. We also consider whether the patient will actually apply the formulation and ensure that the active pharmaceutical ingredient (API) can reach the required target.
The pharmaceutical industry puts a huge amount of resource into the solubility, stability and delivery aspects of derma formulation, but the sensory aspect is something that is largely overlooked, if not ignored altogether. Is it really right to leave the aesthetics of a formulation to an afterthought?
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