Discovery & Development Business Practice, Drug Delivery, Ingredients, Formulation, Dosage Forms, Technology and Equipment, Analytical Science, Trends & Forecasts

Investigating the deagglomeration profiles of dry powder inhaler formulations

Which equipment can measure how the particle size delivered by a dry powder inhaler (DPI) changes as a function of applied air flow rate, providing a deagglomeration profile which can be used to compare the performance of different formulations in a device and improve drug delivery.

06/16/2016

Despite being an increasingly popular method of inhaled drug delivery, dry powder inhalers (DPIs) have relatively low effectiveness in delivery of the active ingredient. Research from Monash University highlights the value of using a Spraytec laser diffraction particle size analyzer to generate powder de-agglomeration profiles which show how dose dispersion changes as a function of the applied air flow rate. This allows efficient comparison of the dispersion performance of different formulations in a device, supporting the efficient matching of devices to formulations.

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