Melt in the Mouth
Orally disintegrating tablets are winning patients over thanks to ease of use, but manufacture is unconventional, which raises a number of challenges and the need for careful consideration.
Elizabeth Hickman |
Though tablets are the most common dosage form, some people have an aversion to – or even fear of – swallowing them. In the mid-1990s, orally disintegrating or dissolving tablets (ODTs), began to appear on the market. Dissolving rapidly when placed on the tongue, the ODT is a convenient dosage form for many groups of people, particularly those likely to have swallowing difficulties, such as mental health, geriatric or pediatric patients. But they are also good for people who simply do not like taking tablets, for whatever reason.
ODTs typically have very good shelf life and do not require refrigeration, which simplifies transportation and storage. Additionally, as the drug is absorbed via the mucous membrane within the oral cavity, it avoids first pass metabolism in the liver and provides rapid onset of action. For that reason, ODTs are particularly popular for therapeutic categories where very quick relief is preferable, such as painkillers, treatments for gastrointestinal disturbances, and anti-allergy medications.
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