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Discovery & Development Business Practice, Ingredients, Formulation, Technology and Equipment, Small Molecules, Analytical Science, Trends & Forecasts

Using Automated Light Scattering Measurements to Support Predictive Protein Formulation Screening

This article explores how fully automated light scattering techniques that screen samples in well plates are being used to identify therapeutic protein formulations most likely to meet commercial targets during early stage development. Ideal biologics are those that are resistant to aggregation and have low-viscosity in high concentration formulation, enabling low-dose parental administration and satisfying stability requirements. Using light scattering to target formulation parameters that reliably predict stability and viscosity at high concentration helps formulators reduce the rate of costly downstream target failures and accelerate development towards clinical submission.

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