Discovery & Development Business Practice, Ingredients, Formulation, Technology and Equipment, Small Molecules, Analytical Science, Trends & Forecasts

Using Automated Light Scattering Measurements to Support Predictive Protein Formulation Screening

High concentration, low-viscosity, stable therapeutic protein formulations are needed to enable low-volume parental administration. This article explores how a fully automated light scattering system supports the rapid screening of small volume samples in well plates for the rapid identification of suitable biologics during early phase development.

06/16/2016

This article explores how fully automated light scattering techniques that screen samples in well plates are being used to identify therapeutic protein formulations most likely to meet commercial targets during early stage development. Ideal biologics are those that are resistant to aggregation and have low-viscosity in high concentration formulation, enabling low-dose parental administration and satisfying stability requirements. Using light scattering to target formulation parameters that reliably predict stability and viscosity at high concentration helps formulators reduce the rate of costly downstream target failures and accelerate development towards clinical submission.

Email*

Choose a password*

I have read and understand the Privacy Notice *

Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

I want to stay up to date with the "Small Molecule" field I want to stay up to date with the Cell and Gene field I want to stay up to date with the Bioprocessing field

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.