Discovery & Development Business Practice, Drug Delivery, Formulation, Small Molecules, Technology and Equipment, Analytical Science, Trends & Forecasts

Using Taylor Dispersion Analysis to determine oligomeric state of insulin

In this article, we take an introductory look at how TDA works, the information it provides and its complementary application to other techniques within the drug development workflow. In addition, example case study data will showcase the performance of TDA relative to dynamic light scattering (DLS) for assessment of the impact of a range of parameters on the monomer-dimer-hexamer equilibrium of insulin.

09/06/2016

Taylor dispersion analysis is an emerging biophysical characterization technique that offers unique benefits in the early stages of biopharmaceutical development – providing answers that established techniques cannot effectively handle.

How TDA works in practice and complements established sizing techniques such as DLS is explained in some examples.

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