When Noses Counterattack
Mimicking the exomes secreted by nasal cells in response to bacteria could boost drug uptake
Maryam Mahdi |
Each breath we take gives bacteria the opportunity to infiltrate our airways. Fortunately, our noses have their own effective mechanisms of defense. Researchers at Massachusetts Eye and Ear claim to have observed, for the first time, cells in the front of the nose detecting pathogenic bacteria in the nasal cavity. In response to bacteria, the cells release swarms of exosomes into the nasal mucus to attack invading microbes. “This is one of the only examples where the immune system actually extends outside the body (in this case into the airway) to fight off bacteria,” says Benjamin Bleier, Associate Professor of Otolaryngology at Massachusetts Eye and Ear and senior author of a new study (1). “The detection of lipopolysaccharide molecular signatures in pathogenic bacteria triggers increased numbers of exosomes, packaged with antimicrobial molecules, to be released.”
Enjoy our FREE content!
Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE and always will be!
Login if you already created an account
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Medicine Maker magazine