A step closer to an off-the-shelf CAR T cell therapy
James Strachan | | Quick Read
Two-out-of-four patients in a 300 million-cell cohort, and one-out-of-three in a 100-cell cohort, achieved a complete response following treatment with CRISPR Therapeutics’ allogeneic CAR T cell therapy CTX110 (1).
The B-cell malignancy treatment was safe at the 300-million dose level and below. The only patient who received a 600 million-cell dose, after initially achieving a complete response, was hospitalized with febrile neutropenia and later died after reactivation of HHV-6 and HHV-6 encephalitis.
CTX110 is derived from healthy donor T cells, which are modified using CRISPR/Cas 9 to i) insert a CAR construct, which binds to cancer cells and activates T cells and ii) knock out the T cell receptor and MHC1, which reduces the risk of graft versus host disease and rejection.
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- CRISPR Therapeutics (2020). Available at: bit.ly/2TxT5Ag