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How to Improve the Capturing of Antibody Fragments

Introduction

Since 1986 and the first approval of therapeutic monoclonal antibody (mAb), the biopharmaceutical industry discovered a broad spectrum of diagnostic and therapeutic applications using antibody engineering. Some of the latest promising developments rely on antibody fragments. Antibody fragments are either separate functional subunits of antibodies or recombinant molecules, which, just like antibodies, are composed of immunoglobulin domains. The most popular fragments are Fab (Fragment antigen binding), scFv (single-chain Fragment variable), diabodies, and nanobodies[1].

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