Discovery & Development Analytical Science

The Sweet Revolution in Mass Spectral Characterization of Glycosylated Antibodies

Protein-based therapeutics represent an increasingly significant part of the biopharmaceutical market.

04/09/2015

Protein-based therapeutics represent an increasingly significant part of the biopharmaceutical market. In order to fully characterize these novel materials, they must be analysed in both their intact form and also when fragmented into sub-units such as peptides.

Unfortunately, these proteins are typically highly heterogeneous, with many possible charge states and structural variations as well as post-translational modifications such as glycosylation or addition of other small functional groups.

Regulatory bodies such as the FDA and EMA require that these biotherapeutics are thoroughly characterized. As a result, extremely high resolution accurate mass spectrometry is required for a complete understanding of the protein structure.

Visit our Webinar Hub

Email*

Choose a password*

I have read and understand the Privacy Notice *

Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

I want to stay up to date with the "Small Molecule" field I want to stay up to date with the Cell and Gene field I want to stay up to date with the Bioprocessing field

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.