Cadence™ Single-pass TFF Coupled with Chromatography Steps Enables Continuous Bioprocessing while Reducing Processing Times and Volumes

contributed by Pall Biotech | 10/23/2017

Catherine Casey¹, M.Sc., Karl Rogler¹, Xhorxhi Gjoka¹,
René Gantier¹, Ph.D., and Engin Ayturk¹, Ph.D.,
¹BioPharm Applications R&D

Continuous bioprocessing initiatives have accelerated in recent years. The transition from batch to continuous bioprocessing offers numerous advantages, including process time savings and lower capital costs due to smaller equipment, tanks, and tubing sizes. Additionally, hold tanks may no longer be needed between unit operations, which can be especially valuable for facilities with limited manufacturing floor space. Furthermore, reduced system hold-up volumes improve product recoveries and also contribute to the smaller system footprint of continuous bioprocessing systems.

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