Case study: Inline Volume Reduction Improves Process Efficiency
contributed by Pall Biotech |
This patented single-pass technology is an opportunity to simplify current TFF processes. It eliminates the conventional TFF recirculation loop and allows product to be concentrated in a single pump pass by utilizing a proprietary flow path and flow ratio control1. The single-pass operation eliminates any mixing or foaming issues and exposes the product to low shear; thus, it is optimal for the processing of fragile and shear-sensitive molecules as well. The single-pass feed flow rates are lower which minimizes the hold-up volume and maximizes product recovery. It also allows higher final concentrations to be achieved because the processing limitations due to minimum working volumes are optimized2-4.
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