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Cleanability and Re-Usability of Cadence™ Inline Diafiltration Modules

The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes in a wide range of applications in the biopharmaceutical industry.

Introduction

This includes buffer exchange for final drug substance, desalting or buffer exchange before or after column chromatography, and small molecule contaminant removal. The single pump pass minimizes shear exposure, eliminates foaming/mixing concerns, and reduces the minimum working volume associated with conventional tangential flow filtration (TFF) systems operating with a recirculation loop.

The Cadence ILDF technology allows for removal factors of ≥ 3-log. Utilizing conventional TFF cassette building blocks with either Delta regenerated cellulose or Omega™ polyethersulfone (PES) membrane ensures accurate scalability and proven selectivity and low protein binding attributes. Table 1 shows the six Cadence ILDF modules currently available.

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