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Harvesting Technology Guide for mAb Processes

Accelerated process development through the identification of optimal platform solutions

Accelerate Your Process Development

Get your guide to cell harvesting using Pall technology. Higher cell densities increase the challenge for harvest clarification technologies. Evaluating every harvesting technology may be time-consuming and can delay process development.

Use the guide to:

  • rapidly identify the most suitable platform technology
  • compare the latest, single-use harvesting technologies

Introduction

The continuing optimization of cell culture processes leads to increases in the productivity of mammalian cell cultures producing higher cell titers and higher monoclonal antibody (mAb)concentrations.

These advances are accompanied by an increasing biomass, including in cell debris and other impurities that combine to increase the practical challenges of clarifying these fluids in preparation for downstream purification.

Extensive evaluation of multiple technologies to identify a single robust platform that will work well across a wide range of processes, especially those with higher cell densities, is time and fluid intensive. This is often not practical. The selection process is then complicated further when expanding the review to include the scalability of the technology, the simplicity of installation or, operation and ultimately the economy, including the scale of capital investment required and ongoing consumable costs.

This guide provides a technology orientation to rapidly identify the best-fit technology, enable quick selection, and fast-track process development. Each of three technology platforms are aligned with known cell culture characteristics and process preferences, and deliver scalable economic solutions to meet your process demands.

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